![]() ![]() Use in the Elderly (approximately 60 years or older)Īntihistamines are most likely to cause dizziness, sedation, and hypotension in elderly patients. In the young pediatric patient, particularly, they may produce excitation. As in adults, antihistamines may diminish mental alertness in pediatric patients. In pediatric patients, especially, antihistamines in overdosage may cause hallucinations, convulsions, or death. WarningsĪntihistamines should be used with considerable caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder-neck obstruction. Hypersensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure. Antihistamines are also contraindicated in the following conditions Use in Nursing Mothersīecause of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers. This drug should not be used in neonates or premature infants. Contraindications Use in Neonates or Premature Infants Antiparkinsonismįor parkinsonism (including drug-induced) in the elderly unable to tolerate more potent agents mild cases of parkinsonism (including drug-induced) in other age groups in other cases of parkinsonism (including drug-induced) in combination with centrally acting anticholinergic agents. Motion Sicknessįor active and prophylactic treatment of motion sickness. Indications and Usage for Diphenhydramine Oral Solutionĭiphenhydramine hydrochloride in the oral form is effective for the following indications: Antihistaminicįor allergic conjunctivitis due to foods mild, uncomplicated allergic skin manifestations of urticaria and angioedema amelioration of allergic reactions to blood or plasma dermatographism as therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled. Little, if any, is excreted unchanged in the urine most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours. Diphenhydramine is widely distributed throughout the body, including the CNS. The duration of activity following an average dose of diphenhydramine hydrochloride is from four to six hours. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.Ī single oral dose of diphenhydramine hydrochloride is quickly absorbed with maximum activity occurring in approximately one hour. ![]() Diphenhydramine Oral Solution - Clinical Pharmacologyĭiphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative effects. ![]() 40, flavoring, purified water, sodium citrate, and sucrose. Inactive Ingredients: Citric acid, D&C Red No. Each 5 mL contains 12.5 mg of diphenhydramine hydrochloride and alcohol 14% for oral administration. ![]()
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